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Treatment with kudzu extract does not cause an increase in alcohol’s intoxicating effects, study finds

Dihydromyricetin, a flavonoid purified from Hovenia dulcis could be another therapeutic candidate for alcohol use disorder [65]. Hypericum perforatum and Salvia miltiorrhiza could be potential natural products to treat alcohol use disorder and will be discussed below, while Scutellaria baicalensis is important in the treatment of liver disease. It is important to place the magnitude of the effects of kudzu extract on alcohol drinking in context.

Side effects of kudzu root

The most popular forms available appear to be powdered drink mixes, capsules, disintegrating tablets, and liquid extract drops. What’s more, the kudzu plant leaves, vine tips, and purple flower blossoms are also edible. You can eat the root as you would other root vegetables, like potatoes or rutabagas. Kudzu roots can be dried and ground into a powder, which some people use as breading for fried foods or as a thickener for soups and sauces.

5 Health Benefits of Kudzu—Including Whether It Can Really Help Treat a Hangover – Well+Good

5 Health Benefits of Kudzu—Including Whether It Can Really Help Treat a Hangover.

Posted: Sun, 07 Oct 2018 07:00:00 GMT [source]

8 Other Effects

While it does not completely eliminate drinking, it is clearly effective in significantly reducing intake, which offers individuals an opportunity to engage in more responsible drinking patterns. As a safe, over-the-counter preparation, kudzu may be used alone in initial attempts to curb alcohol consumption, but it may also become a useful adjunct to the currently available prescription medications. This latter scenario might very well permit the use of lower doses of prescription medications and thus reduce the incidence of side effects. Furthermore, because kudzu extract exerts its beneficial effects within hours of the first dose, it could be administered along with a prescription medication and provide “coverage” until the other medication begins to work.

Kudzu vine extract for alcohol treatment

How can I make myself buy healthier food whilst shopping?

Treatment of alcohol-fed rats (200 mg/kg/day) with FPEt significantly reduced the levels of lipid peroxidation products and protein carbonyl content, as well as prevented the leakage of enzymatic and lipid peroxidation rise [56]. In a word, the FPEt increased the activities of antioxidant enzymes and enhanced the antioxidant properties, which could be the potential mechanisms of action in chronic alcohol-fed mice. The protective effect was possibly due to the bioactive antioxidants in fenugreek seeds such as polyphenols [57,58,59]. As a result, Trigonela foenum-graecum might have a positive influence on suppressing the abnormalities induced by alcohol in chronic alcohol liver diseases through its antioxidant properties. Two parts (roots and flowers) of Pueraria lobata are usually used in traditional medicine. The flowers have been used to treat the problems caused by alcohol drinking due to their ability to enhance acetaldehyde removal [40].

  • The Chinese noticed that people who consumed the plant started to drink less.
  • Separate general linear model ANOVAs for data with repeated measurements were used to analyze the number of drinks per week and the number of heavy drinking days per week.
  • A time course of drinking and sip volumes were obtained by recording the weight of the mug and beer between sips.
  • Anti-inflammatory properties are attributed to decreased prostaglandin E2 and tumor necrosis factor-alpha release, both of which are involved in inflammatory processes (3).
  • Using New Zealand white rabbit and ICR mice as animal models, Kim et al. [84] discovered that after the treatment with hot-water extract of water dropwort in rabbit, the plasma alcohol levels were rapidly decreased, identical to treatment of standard drug, metadoxine.
  • The results showed that berberine inhibited increases of alcohol-induced TNFα and IL-1β expression in gastrointestinal mucosa as well as upstream signals TLR2 and TLR4, and regulated cytokines [129].
  • It was assumed that linoleic acid might be the most active ingredient [92].
  • The government runs the voluntary Traditional Herbal Registration (THR) scheme in an effort to combat this problem.

“It is also possible that there is another, as yet undiscovered compound in the mixture that accounts for the effects. Thus, the mechanism of action of the kudzu extract remains unknown.” The lack of side effects could, with more research, make kudzu treatment an option for teens, pregnant women “and other vulnerable populations where a lack of medication toxicity is not only desirable but also necessary,” Lukas and colleagues write. Participants in the study were allowed to watch television or movies in the mock studio apartment while choosing drinks from a refrigerator stocked with a favorite brand of beer and other nonalcoholic drinks. “Investigators may not be willing to take the extra steps that might be necessary to conduct such a study,” such as extracting the critical isoflavones from kudzu and partnering with clinical researchers, Overstreet says.

Applications of Pueraria lobata in treating diabetics and reducing alcohol drinking

A total of 21 adult males (17 Caucasian, 1 African American, 2 Hispanic, 1 Middle Eastern; mean age 23.8 ± 3.46 years, range 21–33) were recruited through advertisements in local and college newspapers and flyers posted in the Boston area. Persons who responded to these advertisements were given a brief telephone screen, and invited to the laboratory for further evaluations. Persons of Asian descent were excluded kudzu to stop drinking because of their known increased flushing reaction to alcohol. Individuals with a body mass index (BMI) outside the range of 18–25 kg/m2 were also excluded. We have made extensive use of wrist actigraphy as a measure of sleep/wake activity and as a method of tracking alcohol drinking behavior. The patterns of drinking during baseline and after kudzu treatment are shown for one representative subject in Fig 6.

6 Data Analysis

Kudzu vine extract for alcohol treatment

Effect size is reported using the variance-accounted for statistic Partial Eta-Squared (η2Partial). All tests were two-sided with significance level of 0.05 and were performed using SPSS software (version 19.0, IBM SPSS, Inc, Chicago, IL). Although the common pathogenesis of metabolic syndrome is still not fully understood, recent studies suggest that kudzu root extract and puerarin could reverse the pathological abnormalities induced by high glucose levels in vitro and In vivo. In high glucose-treated preadipocytes, co-incubation of puerarin considerably potentiated glucose uptake dose-dependently (Xu et al, 2005). A similar effect was observed in isolated rat soleus muscle (Hsu et al, 2003).

  • A possible mechanism was that Salvia miltiorrhiza curbed alcohol absorption from the gastrointestinal tract [110].
  • Short-term effects on blood and liver tests occurred in a small study of postmenopausal women.
  • There are many ways, both medical and traditional, that are used to treat alcohol abuse or dependence.
  • The mRNA levels of GPx, phospholipid hydroperoxide, and selenoprotein were significantly improved compared with the alcohol-treated embryos [95].
  • Natural products for the prevention and treatment of hangover and alcohol use disorder.
  • Because of this effect, it might also be helpful for people who have quit drinking and want to make sure that a potential slip doesn’t become a full-blown relapse.

Medications that can harm the liver (Hepatotoxic drugs) interacts with KUDZU

1 Participant Flow Through Study

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